Would you go in debt for a car or house?
Unless you can pay a mortgage off in ten years it isn't worth it to buy. Renting is better.
Anything else, never again. Your primary residence is the only place going into debt can make sense. Every time I make a mortgage payment, as opposed to rent, its like money in the bank. In fact I stand to make 50% on my home when I sell if the market stays where it is. That's a good move.